Pain – Cold Food & Drink

The primary reason for pain from cold is erosion of the enamel, which protects the dentin below. This erosion can be caused by dental caries, an unwanted biofilm on the tooth’s surface, combined with eating, or drinking acidic foods and sugars.

As surfaces erode and cavities form, the dentin becomes exposed, leading to pain from cold foods or drinks. This sensation is perceived as a reaction from nerves within the tooth, a process that has been better understood thanks to recent research.

The Core Discoveries

Odontoblasts are cells that form part of the dental pulp’s outer surface below the dentin and are involved in the formation of dentin (dentinogenesis). Research from 2021 found that these cells play a significant role in dental pain from cold. Odontoblasts contain a molecule called TRPC5, which makes them integral to our dental cold-sensing system. This molecule is found in higher levels in areas with erosion or dental caries.

The research demonstrated that the TRPC5 protein opens channels in the membrane of odontoblasts, enabling other molecules, such as calcium, to enter and interact with the cell. This process triggers nerves to fire, creating the sensation of pain and cold hypersensitivity.

Potential For Benefit

As noted by the lead investigator, targeting the TRPC5 molecule presents possibilities for treatment. This could lead to new applications in toothpastes, chewing gum, or dental patches designed to alleviate cold sensitivity. Traditional remedies, such as clove oil (which contains eugenol that blocks TRPC5), are already in use and could see enhanced applications based on this research.

However, addressing the underlying cause remains essential. Good oral hygiene, regular dental check-ups, and restorative treatments are crucial for long-term dental health and pain prevention.

This discovery not only provides insight into managing cold sensitivity but also emphasizes the importance of tailored dental care for long-term solutions